A New Perspective on the Prediction and Treatment of Stroke: The Role of Uric Acid
Bingrui Zhu1,2 · Xiaobin Huang3 · Jiahao Zhang1,2 · Xiaoyu Wang1,2 · Sixuan Tian1,2 · Tiantong Zhan1,2 · Yibo Liu1,2 · Haocheng Zhang1,2 · Sheng Chen1,2 · Cheng Yu31 Department of Neurosurgery, The Second Afliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
2 Clinical Research Center for Neurological Diseases of Zhejiang Province, Hangzhou 310009, China
3 Department of Neurosurgery, The Second People’s Hospital of Quzhou, Quzhou 324000, China
Abstract
Stroke, a major cerebrovascular disease, has high morbidity and mortality. Effective methods to reduce the risk and improve the prognosis are lacking. Currently, uric acid (UA) is associated with the pathological mechanism, prognosis, and therapy of stroke. UA plays pro/anti-oxidative and pro-inflammatory roles in vivo. The specific role of UA in stroke, which may have both neuroprotective and damaging effects, remains unclear. There is a U-shaped association between serum uric acid (SUA) levels and ischemic stroke (IS). UA therapy provides neuroprotection during reperfusion therapy for acute ischemic stroke (AIS). Urate-lowering therapy (ULT) plays a protective role in IS with hyperuricemia or gout. SUA levels are associated with the cerebrovascular injury mechanism, risk, and outcomes of hemorrhagic stroke. In this review, we summarize the current research on the role of UA in stroke, providing potential targets for its prediction and treatment.
Keywords
Uric acid; Stroke; Prediction; Treatment; Uric acid therapy; Urate-lowering therapy
