Xi Li1,2 · Chunshui Ye3 · Min Wang4 · Patrick Kwan5,6,7,8 · Xin Tian5 · Yanke Zhang2,91 Jining Medical University, Jining 272000, China
2 Department of Neurology, Afliated Hospital of Jining Medical University, Jining 272000, China
3 Department of Gastrointestinal Surgery, Jining No. 1 People’s Hospital, Jining 272000, China
4 Department of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
5 Department of Neurology, The First Afliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, Chongqing 400016, China
6 Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia
7 Department of Neurology, Alfred Health, Melbourne, VIC 3004, Australia
8 Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Melbourne, VIC 3004, Australia
9 Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
Abstract
The nervous system is the dominant regulatory system in the human body. The traditional theory is that tumors lack innervation. However, an increasing number of studies have shown complex bidirectional interactions between tumors and the nervous system. Globally, colorectal cancer (CRC) is the third most common cancer. With the rise of tumor neuroscience, the role of nervous system imbalances in the occurrence and development of CRC has attracted increasing amounts of attention. However, there are still many gaps in the research on the interactions and mechanisms involved in the nervous system in CRC. This article systematically reviews emerging research on the bidirectional relationships between the nervous system and CRC, focusing on the following areas: (1) Effects of the nervous system on colon cancer. (2) Effects of CRC on the nervous system. (3) Treatment of CRC associated with the nervous system.
Keywords
Nervous system; Colorectal cancer; Tumor microenvironment; Cancer treatment; Tumor neuroscience
