Ying Bai1 · Hui Ren1 · Liang Bian1 · You Zhou1 · Xinping Wang1 · Zhongli Xiong1 · Ziqi Liu1 · Bing Han1 · Honghong Yao1,2,31 Department of Pharmacology, Jiangsu Provincial Key Laboratory, School of Medicine, Southeast University, Nanjing 210009, China
2 Co-innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China
3 Institute of Life Sciences, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210009, China
Abstract
Non-coding RNAs (ncRNAs) are a class of functional RNAs that play critical roles in different diseases. NcRNAs include microRNAs, long ncRNAs, and circular RNAs. They are highly expressed in the brain and are involved in the regulation of physiological and pathophysiological processes of central nervous system (CNS) diseases. Mounting evidence indicates that ncRNAs play key roles in CNS diseases. Further elucidating the mechanisms of ncRNA underlying the process of regulating glial function that may lead to the identification of novel therapeutic targets for CNS diseases.
Keywords
Noncoding RNA; MicroRNA; Long noncoding RNA; Circular RNA; Astrocytes; Microglia; Oligodendrocytes
