Progress of the Impact of Terahertz Radiation on Ion Channel Kinetics in Neuronal Cells
Yanjiang Liu1 · Xi Liu1,2,3,4,5,6 · Yousheng Shu1,2,4,5 · Yuguo Yu1,2,3,71 Research Institute of Intelligent and Complex Systems, Fudan University, Shanghai 200433, China
2 MOE Frontiers Center for Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200433, China
3 Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China
4 Department of Neurology, Huashan Hospital, Fudan University, Shanghai 20043, China
5 Institute for Translational Brain Research, Fudan University, Shanghai 200433, China
6 Department of Neurosurgery, Jinshan Hospital of Fudan University, Shanghai 201508, China
7 Shanghai Artifcial Intelligence Laboratory, Shanghai 200232, China
Abstract
In neurons and myocytes, selective ion channels in the plasma membrane play a pivotal role in transducing chemical or sensory stimuli into electrical signals, underpinning neural and cardiac functionality. Recent advancements in biomedical research have increasingly spotlighted the interaction between ion channels and electromagnetic fields, especially terahertz (THz) radiation. This review synthesizes current findings on the impact of THz radiation, known for its deep penetration and non-ionizing properties, on ion channel kinetics and membrane fluid dynamics. It is organized into three parts: the biophysical effects of THz exposure on cells, the specific modulation of ion channels by THz radiation, and the potential pathophysiological consequences of THz exposure. Understanding the biophysical mechanisms underlying these effects could lead to new therapeutic strategies for diseases.
Keywords
Ion channel kinetics; Terahertz radiation; Electromagnetic feld interactions; Neuron; Cell membrane
