Histaminergic Innervation of the Ventral Anterior Thalamic Nucleus Alleviates Motor Deficits in a 6-OHDA-Induced Rat Model of Parkinson’s Disease
Han‑Ting Xu1
· Xiao‑Ya Xi1
· Shuang Zhou1
· Yun‑Yong Xie1 · Zhi‑San Cui1
· Bei‑Bei Zhang1
· Shu‑Tao Xie1
·
Hong‑Zhao Li1
· Qi‑Peng Zhang1,2 · Yang Pan4
· Xiao‑Yang Zhang1,2 · Jing‑Ning Zhu1,2,3
2025,41(4):551–568 [
Abstract] [
SpringerLink]
Dysregulation of Iron Homeostasis Mediated by FTH Increases Ferroptosis Sensitivity in TP53-Mutant Glioblastoma
Xuejie Huan1
· Jiangang Li1
· Zhaobin Chu3
· Hongliang Zhang4
· Lei Cheng4
·
Peng Lun4
· Xixun Du1
· Xi Chen1
· Qian Jiao1 · Hong Jiang1,2
2025,41(4):569–582 [
Abstract] [
SpringerLink]
Deciphering the Role of Shank3 in Dendritic Morphology and Synaptic Function Across Postnatal Developmental Stages in the Shank3B KO Mouse
Jing Yang1
· Guaiguai Ma2
· Xiaohui Du1
· Jinyi Xie2
·
Mengmeng Wang2
· Wenting Wang2
· Baolin Guo2,3 ·
Shengxi Wu2
2025,41(4):583–599 [
Abstract] [
SpringerLink]
Pseudogene Lamr1-ps1 Aggravates Early Spatial Learning Memory Deficits in Alzheimer’s Disease Model Mice
Zhuoze Wu1 · Xiaojie Liu1
· Yuntai Wang1,2 ·
Zimeng Zeng1
· Wei Chen1
· Hao Li3
2025,41(4):600–614 [
Abstract] [
SpringerLink]
Cation Channel TMEM63A Autonomously Facilitates Oligodendrocyte Differentiation at an Early Stage
Yue‑Ying Wang1,2,3 · Dan Wu1
· Yongkun Zhan4,5 · Fei Li6 · Yan‑Yu Zang1
·
Xiao‑Yu Teng1,3 · Linlin Zhang7
· Gui‑Fang Duan8
· He Wang2
· Rong Xu9
·
Guiquan Chen1
· Yun Xu1 · Jian‑Jun Yang2
· Yongguo Yu4,10 · Yun Stone Shi1,3
2025,41(4):615–632 [
Abstract] [
SpringerLink]
Reprogramming miR-146b-snphb Signaling Activates Axonal Mitochondrial Transport in the Zebrafish M-cell and Facilitates Axon Regeneration After Injury
Xin‑Liang Wang2 · Zong‑Yi Wang2
·
Xing‑Han Chen2
· Yuan Cai3
· Bing Hu1,2
2025,41(4):633–648 [
Abstract] [
SpringerLink]
Associative Learning-Induced Synaptic Potentiation at the Two Major Hippocampal CA1 Inputs for Cued Memory Acquisition
Bing‑Ying Wang1 · Bo Wang1
· Bo Cao1
· Ling‑Ling Gu1
· Jiayu Chen1
· Hua He3
·
Zheng Zhao1 · Fujun Chen2 · Zhiru Wang1
2025,41(4):649–664 [
Abstract] [
SpringerLink]
Neuronal Regulation of Feeding and Energy Metabolism: A Focus on the Hypothalamus and Brainstem
Jing Chen2 · Meiting Cai1 · Cheng Zhan1
2025,41(4):665–675 [
Abstract] [
SpringerLink]
Type 2 Diabetes Mellitus Exacerbates Pathological Processes of Parkinson's Disease: Insights from Signaling Pathways Mediated by Insulin Receptors
Shufen Liu1,2 · Tingting Liu1,2 · Jingwen Li2
· Jun Hong2
· Ali A. Moosavi‑Movahedi3
·
Jianshe Wei1,2
2025,41(4):676–690 [
Abstract] [
SpringerLink]
The Role and Mechanisms of Ubiquitin-Proteasome System-Mediated Ferroptosis in Neurological Disorders
Xin Liu1,2 · Wei Wang3
· Qiucheng Nie1,4 · Xinjing Liu1,4 · Lili Sun1,4 · Qiang Ma3
·
Jie Zhang1,2 · Yiju Wei1,4
2025,41(4):691–706 [
Abstract] [
SpringerLink]
Direct Hippocampal and Thalamic Inputs to Layer 3 Pyramidal Cells in the Medial Entorhinal Cortex Revealed by Monosynaptic Rabies Tracing
Ze Chen1 · Dietmar Schmitz1,2,3,4,5 ·
John J. Tukker2
2025,41(4):707–712 [
Abstract] [
SpringerLink]
Dynamic Routing of Theta-Frequency Synchrony in the Amygdalo-Hippocampal-Entorhinal Circuit Coordinates Retrieval of Competing Memories
Jiahua Zheng1
· Yiqi Sun1
· Fuhai Wang1
· Zhongyu Xie1
· Qianyun Wang1
·
Jian‑Ya Peng1
· Jianguang Ni1
2025,41(4):713–718 [
Abstract] [
SpringerLink]
Exploring the Therapeutic Potential of Psychedelics in Chronic Pain Management: A New Frontier in Medicine
Cong Lin1
· Xue Wang2
· Xiaohui Wang1,3
2025,41(4):719–722 [
Abstract] [
SpringerLink]
Halting the Progression of Alzheimer’s Disease: Is the Goal in Sight?
Yu‑Juan Jia1,2 · Xuan‑Yue Wang3
· Jie Liu2
· Yan‑Jiang Wang4,5 ·
Colin L. Masters6 · Jun‑Hong Guo1
2025,41(4):723–727 [
Abstract] [
SpringerLink]
To Attack or Not: A Neural Circuit Coding Sexually Dimorphic Aggression
Qiuhong Xin1,2 · Hailan Hu1,2
2025,41(4):728–730 [
Abstract] [
SpringerLink]
The Paraventricular Hypothalamus: A Sorting Center for Visceral and Somatic Pain
Li Sun1,2,3 · Shumin Duan1,2,3
2025,41(4):731–733 [
Abstract] [
SpringerLink]
Bridge RNA-Guided Genetic Recombination Tools for Treating Neurodegenerative Nucleotide Repeat Disorders
Fengshi Li1
· Jingyu Yu1
· Peng Wang1
· Tianwen Li1
·
Qisheng Tang1
· Jianhong Zhu1
2025,41(4):734–736 [
Abstract] [
SpringerLink]
Histamine H1 Receptor in Medial Septum Cholinergic Circuit: New Hope for Fear-related Disorders?
Kang Liu1,2
2025,41(4):737–740 [
Abstract] [
SpringerLink]
About the Cover
The motor symptoms of Parkinson's disease (PD) are believed to result from excessive inhibitory signaling from the basal ganglia to the motor thalamus. Xu et al. explored histamine's role in the ventral anterior nucleus (VA) of the thalamus, showing that its histaminergic afferents compensate for Parkinsonian motor deficits. On the cover, histaminergic terminals target VA neurons, releasing histamine to activate them and eventually alleviating the motor deficits in a rat model of PD. (Cover art by Dr. Yefei Li)
