Joint Multi-modal Parcellation of the Human Striatum: Functions and Clinical Relevance

Xiaojin Liu 1,2 • Simon B. Eickhoff 1,2 • Felix Hoffstaedter 1,2 • Sarah Genon 1,2 • Svenja Caspers 3,4 • Kathrin Reetz 6 • Imis Dogan 5,6 • Claudia R. Eickhoff 3,7 • Ji Chen 1,2 • Julian Caspers 3,8 • Niels Reuter 1,2 • Christian Mathys 8,9 • Andre´ Aleman 10 • Renaud Jardri 11 • Valentin Ried 12 • Iris E. Sommer 9 • Kaustubh R. Patil 1,2


1 Institute of Neuroscience and Medicine (INM-7, Brain and Behaviour), Research Centre Ju¨lich, Ju¨lich, Germany

2 Institute of Systems Neuroscience, Heinrich Heine University Du¨sseldorf, Du¨sseldorf, Germany

3 Institute of Neuroscience and Medicine (INM-1), Research Centre Ju¨lich, 52428 Ju¨lich, Germany

4 Institute for Anatomy I, Medical Faculty, Heinrich Heine University Du¨sseldorf, 40225 Du¨sseldorf, Germany

5 Ju¨lich Aachen Research Alliance-BRAIN (JARA) Institute of Molecular Neuroscience and Neuroimaging, Forschungszentrum Ju¨lich, Rheinisch Westfa¨llische Technische Hochschule (RWTH) Aachen University, 52074 Aachen, Germany

6 Department of Neurology, Rheinisch Westfa¨llische Technische Hochschule (RWTH) Aachen University, 52074 Aachen, Germany

7 Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, University of Du¨sseldorf, 40225 Du¨sseldorf, Germany

8 Department of Diagnostic and Interventional Radiology, Medical Faculty, University of Du¨sseldorf, 40225 Du¨sseldorf, Germany

9 Institute of Radiology and Neuroradiology, Evangelisches Krankenhaus, University of Oldenburg, 26129 Oldenburg, Germany

10 Department of Neuroscience, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands

11 SCALab (CNRS UMR9193) & CHU de Lille, Hoˆpital Fontan, Poˆle de Psychiatrie (CURE), Universite´ de Lille, 59037 Lille, France

12 Departments of Neuroradiology, Nuclear Medicine and Neuroimaging Center, Technische Universita¨t Mu¨nchen, 80333 Munich, Germany

Abstract

The human striatum is essential for both low- and high-level functions and has been implicated in the pathophysiology of various prevalent disorders, including Parkinson’s disease (PD) and schizophrenia (SCZ). It is known to consist of structurally and functionally divergent subdivisions. However, previous parcellations are based on a single neuroimaging modality, leaving the extent of the multi-modal organization of the striatum unknown. Here, we investigated the organization of the striatum across three modalities—resting-state functional connectivity, probabilistic diffusion tractography, and structural covariance—to provide a holistic convergent view of its structure and function. We found convergent clusters in the dorsal, dorsolateral, rostral, ventral, and caudal striatum. Functional characterization revealed the anterior striatum to be mainly associated with cognitive and emotional functions, while the caudal striatum was related to action execution. Interestingly, significant structural atrophy in the rostral and ventral striatum was common to both PD and SCZ, but atrophy in the dorsolateral striatum was specifically attributable to PD. Our study revealed a cross-modal convergent organization of the striatum, representing a fundamental topographical model that can be useful for investigating structural and functional variability in aging and in clinical conditions.

Keywords

Striatum; Multi-modal; Connectivity-based parcellation; Convergent clusters; Voxel-based morphometry; Parkinson’s disease; Schizophrenia

[SpringerLink]

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