Major Depressive Disorder: Advances in Neuroscience Research and Translational Applications


Zezhi Li1,2• Meihua Ruan3• Jun Chen1,5• Yiru Fang1,4,5



1 Clinical Research Center and Division of Mood Disorders of Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China

2 Department of Neurology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

3 Shanghai Institute of Nutrition and Health, Shanghai Information Center for Life Sciences, Chinese Academy of Science, Shanghai 200031, China

4 Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Science, Shanghai 200031, China

5 Shanghai Key Laboratory of Psychotic Disorders, Shanghai 201108, China



Abstract

Major depressive disorder (MDD), also referred to as depression, is one of the most common psychiatric disorders with a high economic burden. The etiology of depression is still not clear, but it is generally believed that MDD is a multifactorial disease caused by the interaction of social, psychological, and biological aspects. Therefore, there is no exact pathological theory that can independently explain its pathogenesis, involving genetics, neurobiology, and neuroimaging. At present, there are many treatment measures for patients with depression, including drug therapy, psychotherapy, and neuromodulation technology. In recent years, great progress has been made in the development of new antidepressants, some of which have been applied in the clinic. This article mainly reviews the research progress, pathogenesis, and treatment of MDD.

Keywords

Major depressive disorder ; Pathogenesis ; Treatment ; Progress

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