Neuronal failure in Alzheimer’s disease: a view through the oxidative stress looking-glass
David J. Bonda1, Xinglong Wang1, Hyoung-Gon Lee1, Mark A. Smith1,†, George Perry1,2, Xiongwei Zhu1
1Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
2UTSA Neurosciences Institute and Department of Biology, University of Texas at San Antonio, San Antonio, Texas, USA
† Author deceased.
Considerable debate and controversy surround the cause(s) of Alzheimer’s disease (AD). To date, several theories have gained notoriety, however none is universally accepted. In this review, we provide evidence for the oxidative stress-induced AD cascade that posits aged mitochondria as the critical origin of neurodegeneration in AD.
Alzheimer’s disease; amyloid-beta; free radicals; mitochondria; mitochondrial dynamics; oxidative stress