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Current Issue Table of Contents: 15 Volume 37, Issue. 7, July, 2021

Impact Factor 5.203*
Journal Citation Reports Q2

About the Cover

Nerve agents are among the deadliest poisons known to man. In this issue, Wang et al. demonstrate the “dual-switch” function of TRPV4 in the treatment of nerve agent intoxication. TRPV4 is a key target of soman poisoning due to its modulation of NMDA-mediated excitotoxicity in the early stage of poisoning and NLRP3-medicated neuroinflammation in the late stage. As shown in this cover image, the brain is attacked by the nerve agent soman, and a defensive line formed by blocking TRPV4 and its downstream NMDAR and NLRP3 pathways can effectively protects the brain against the nerve agent. See pages 905–920. (Cover image designed by Shuai Wang).

Shumin Duan

Ru-Rong Ji

Editorial Board


Chronic Exposure to Hypoxia Inhibits Myelinogenesis and Causes Motor Coordination Deficits in Adult Mice
Lin Chen • Shu-Yu Ren • Rui-Xue Li • Kun Liu • Jing-Fei Chen • Yu-Jian Yang • Yong-Bin Deng • Han-Zhi Wang • Lan Xiao • Feng Mei • Fei Wang [SpringerLink]

Overexpression of MECP2 in the Suprachiasmatic Nucleus Alters Circadian Rhythm and Induces Abnormal Social Behaviors
Hailin Liu • Zilong Qiu [SpringerLink]

Reprogramming Glial Cells into Functional Neurons for Neuro-regeneration: Challenges and Promise
Fengchao Wang • Leping Cheng • Xiaohui Zhang [SpringerLink]

A Standardized Protocol for the Induction of Specific Social Fear in Mice
Junqiang Zheng • Yuanyuan Tian • Haifeng Xu • Linfan Gu • Han Xu [SpringerLink]

Evidence of Altered Cortical Processing of Dynamic Lexical Tone Pitch Contour in Chinese Children with Autism
Luodi Yu • Dan Huang • Suiping Wang • Xueyuan Wu • Yang Chen • Yang Zhang [SpringerLink]

Know Thy Enemy: Untangling the Mysteries of Neuropathic Pain
Mahar Fatima • Chia Chun Hor • Bo Duan [SpringerLink]

Effect of Sodium Salicylate on Calcium Currents and Exocytosis in Cochlear Inner Hair Cells: Implications for Tinnitus Generation
Ting Fan • Meng-Ya Xiang • Ruo-Qiao Zhou • Wen Li • Li-Qin Wang • Peng-Fei Guan • Geng-Lin Li • Yun-Feng Wang • Jian Li [SpringerLink]

Steroid Receptor Coactivator 3 Regulates Synaptic Plasticity and Hippocampus-dependent Memory
Hai-Long Zhang • Bing Zhao • Pin Yang • Yin-Quan Du • Wei Han • Jianming Xu3 • Dong-Min Yin [SpringerLink]


Activated Natural Killer Cells Hit Neurogenesis in the Aging Brain
Angelica Cuapio • Hans-Gustaf Ljunggren [SpringerLink]

STING-ing Pain: How Can Pro-inflammatory Signaling Attenuate Pain?
Wolfgang Liedtke [SpringerLink]

The Parabrachial Nucleus as a Key Regulator of Neuropathic Pain
Zilong Wang • Zhen-Zhong Xu [SpringerLink]

Combination of Biomedical Techniques and Paradigms to Improve Prognostications for Disorders of Consciousness
Ming Song • Jianghong He • Yi Yang • Tianzi Jiang [SpringerLink]

Autologous Transplantation for Parkinson's Disease Patients: Feasibility and Challenge
Qi Zhang • Yanlin Wang • Yukai Wang • Han Liu • Huifang Sun • Zhuoya Wang • Changhe Shi • Jing Yang • Yuming Xu [SpringerLink]

Breakthrough in Structural and Functional Dissection of the Hypothalamo-Neurohypophysial System
Ying Wang • Huamin Xu • Xia Zhang [SpringerLink]

Top-down Modulation of Outcome Processing in Primary Sensory Cortex for Flexible Behavior
Qi Cheng • Chengyu T. Li [SpringerLink]

Brain Energy Improvement as an Emerging Approach for Alzheimer’s Disease Treatment
Xiaoli Pan • Shaoming Sang • Chunjiu Zhong [SpringerLink]

Getting Lost: Place Cells and Grid Cells in Rodent Models of Alzheimer’s Disease
Xiaoyang Long • Yuan Tao • Xi-Chan Chen • Bin Deng • Jing Cai • Sheng-Jia Zhang [SpringerLink]

A Bridge between the Innate Immunity System and Amyloid-β Production in Alzheimer’s Disease
Xiying Wang [SpringerLink]

New Insight into the Origins of Itch and Pain: How Are Itch and Pain Signals Coded and Discriminated by Primary Sensory Neurons?
Yue Hu • Wen-Qi Shan • Bin Wu • Tong Liu [SpringerLink]

ESCAPE-NA1 Trial Brings Hope of Neuroprotective Drugs for Acute Ischemic Stroke – Highlights of the Phase 3 Clinical Trial on Nerinetide
Xin-Fu Zhou [SpringerLink]


The Risk and Prevention of Novel Coronavirus Pneumonia Infections Among Inpatients in Psychiatric Hospitals
Yuncheng Zhu • Liangliang Chen • Haifeng Ji • Maomao Xi • Yiru Fang • Yi Li [SpringerLink]

Expert Consensus on the Care and Management of Patients with Cognitive Impairment in China
Academy of Cognitive Disorders of China (ACDC) • Yuliang Han • Jianjun Jia • Xia Li • Yang Lv • Xuan Sun • Shanshan Wang • Yongjun Wang • Zhiwen Wang • Jintao Zhang • Jiong Zhou & Yuying Zhou [SpringerLink]

An Overview of the Expert Consensus on the Prevention and Treatment of Gaming Disorder in China (2019 Edition)
Yu-Tao Xiang • Yu Jin • Ling Zhang • Lu Li • Gabor S. Ungvari • Chee H. Ng • Min Zhao & Wei Hao [SpringerLink]

Perspective on Etiology and Treatment of Bipolar Disorders in China: Clinical Implications and Future Directions
Zuowei Wang • Chen Jun • Keming Gao • Haichen Yang • Yiru Fang [SpringerLink]

Standardized Operational Protocol for Human Brain Banking in China
Wenying Qiu • Hanlin Zhang • Aimin Bao • Keqing Zhu • Yue Huang • Xiaoxin Yan • Jing Zhang • Chunjiu Zhong • Yong Shen • Jiangning Zhou • Xiaoying Zheng • Liwei Zhang • Yousheng Shu • Beisha Tang • Zhenxin Zhang • Gang Wang • Ren Zhou • Bing Sun • Changlin Gong • Shumin Duan & Chao Ma [SpringerLink]

Emerging role of Toll-like receptors in the control of pain and itch
Tong Liu1, Yong-Jing Gao1,2 and Ru-Rong Ji1 [SpringerLink]

Oxidative stress in Alzheimer's disease
Zhichun Chen1,2, Chunjiu Zhong1,2 [SpringerLink]

An Overview of Autism Spectrum Disorder, Heterogeneity and Treatment Options OPEN ACCESS
Anne Masi1 • Marilena M. DeMayo1 • Nicholas Glozier1 • Adam J. Guastella1 [SpringerLink]

Caspase-3 activation as a bifurcation point between plasticity and cell death
Shikha Snigdha, Erica D Smith, G Aleph Prieto, Carl W Cotman [SpringerLink]

Behavioral animal models of depression
Hua-Cheng YAN, Xiong CAO, Manas Das, Xin-Hong ZHU, Tian-Ming GAO [SpringerLink]

The glial scar in spinal cord injury and repair
Yi-Min Yuan, Cheng He [SpringerLink]

Roles of the hippocampal formation in pain information processing
Ming-Gang LIU, Jun CHEN [SpringerLink]


The Risk and Prevention of Novel Coronavirus Pneumonia Infections Among Inpatients in Psychiatric Hospitals
Yuncheng Zhu 1 • Liangliang Chen 2 • Haifeng Ji 2 • Maomao Xi 3 • Yiru Fang 1,5,6 • Yi Li 4 [SpringerLink]

An Overview of Autism Spectrum Disorder, Heterogeneity and Treatment Options OPEN ACCESS
Anne Masi1 • Marilena M. DeMayo1 • Nicholas Glozier1 • Adam J. Guastella1 [SpringerLink]

Pharmacological Modulation of Vagal Nerve Activity in Cardiovascular Diseases
Longzhu Liu • Ming Zhao • Xiaojiang Yu • Weijin Zang* [SpringerLink]

Gene Editing to the Rescue: Reversal of Social Deficits Associated with MECP2 Duplication
Zi-Xian Yu 1,2,3 • Dan-Yang Wang 1,2,3 • Xiao-Hong Xu 1,3 [SpringerLink]

Regulation of Pain and Itch by TRP Channels
Carlene Moore1 • Rupali Gupta1 • Sven-Eric Jordt2 • Yong Chen1,* • Wolfgang B. Liedtke1,2,* [SpringerLink]

Spinal Circuits Transmitting Mechanical Pain and Itch
Bo Duan1,* • Longzhen Cheng2,* • Qiufu Ma3,* [SpringerLink]

Neuronal Network Dissection with Neurotropic Virus Tracing
Xiaoping Rao 1 • Jie Wang 1,2 [SpringerLink]


Special Issue: Purinergic Signaling in the Central Nervous System in Health and Disease
Guest Editor: Yong Tang, Peter Illes, and Guang-Yin Xu
2020 Vol 36 Issue 11

[PDF] [SpringerLink]

Special Issue:Bipolar Disorders
Guest Editor:Yiru Fang
2019 Vol 35 Issue 4

[PDF] [SpringerLink]

Special Issue: Neurotechniques
Guest Editor: Guo-Qiang Bi
2019 Vol 35 Issue 3

[PDF] [SpringerLink]

Special Issue:Human Brain Bank: Construction and Research
Guest Editor: Chao Ma and Dick F. Swaab
2019 Vol 35 Issue 2

[PDF] [SpringerLink]

Special Issue: Regulation of Autonomic Nervous System
Guest Editor: Qing-Hui Chen
2019 Vol 35 Issue 1

[PDF] [SpringerLink]